Randomized clinical trial comparing high versus standard dose of ribavirin plus peginterferon alfa-2a in hepatitis C genotype 3 and high viral load. Dargen-3 study
✍ Scribed by Fernández-Rodríguez, Conrado M.; Morillas, Rosa María; Masnou, Helena; Navarro, José María; Bárcena, Rafael; González, José Manuel; Martín-Martín, Leticia; Poyato, Antonio; Miquel-Planas, Mireia; Jorquera, Francisco; Casanovas, Teresa; Salmerón, Javier; Calleja, José Luis; Solà, Ricard; Alonso, Sonia; Planas, Ramón; Romero-Gomez, Manuel
- Book ID
- 122187525
- Publisher
- Elsevier Science
- Year
- 2014
- Tongue
- Spanish
- Weight
- 852 KB
- Volume
- 37
- Category
- Article
- ISSN
- 0210-5705
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This study tested the hypothesis that high-dose peginterferon alfa-2a (PEG-IFNalpha-2a) for the first 12 weeks would increase early and sustained virological response (SVR) rates in patients with chronic hepatitis C genotype 1. Eight hundred ninety-six patients were randomized 1:1 to 360 microg (n =
öschenberger, 10 for the Austrian Hepatitis Study Group We compared the efficacy and tolerability of 24 weeks of treatment with ribavirin 800 mg/day (group A) or 400 mg/day (group B) plus peginterferon alfa-2a 180 g/week in treatment-naive patients infected with hepatitis C virus (HCV) genotype 2 o