Randomised study of ticarcillin, cefamandole with or without tobramycin in febrile, neutropenic patients with solid tumors
✍ Scribed by Page, Jonathan P. ;Levi, John A. ;Woods, Robert L. ;Chan, Wing K. ;Bell, David R. ;Aroney, Rodney S.
- Publisher
- John Wiley and Sons
- Year
- 1987
- Tongue
- English
- Weight
- 698 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0098-1532
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✦ Synopsis
A prospective randomised study was conducted comparing the efficacy and toxicity of the antibiotics ticarcillin and cefamandole (TC)
with or without tobramycin 0 in 100 febrile neutropenic patients with solid tumours undergoing conventional chemotherapy. In this study, neutropenia 0.05). Patients with initial shock bacteremia, pulmonary infection, or gram-negative sepsis responded relatively poorly. Neutrophil nadir and pathogen susceptibility did not influence outcome. Antibiotic toxicity was minimal with no tobramycin-related nephrotoxicity. These results are broadly comparable to those observed with leukemic patients, but the relatively short duration of neutropenia in the solid-tumour patients appears to minimize the need for additional antibiotics provided there is adequate antimicrobial coverage with the initial choice of antibiotics.