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Randomised phase II trial of 4 dose levels of single agent docetaxel in performance status (PS) 2 patients with advanced non-small cell lung cancer (NSCLC): DOC PS2 trial. Manchester lung cancer group

✍ Scribed by Califano, Raffaele; Griffiths, Richard; Lorigan, Paul; Ashcroft, Linda; Taylor, Paul; Burt, Paul; Lee, Lip; Chittalia, Abbas; Harris, Margaret; Faivre-Finn, Corinne; Thatcher, Nick; Blackhall, Fiona


Book ID
119320533
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
488 KB
Volume
73
Category
Article
ISSN
0169-5002

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## Background. A prior Phase I1 study of a 100-mg/m2 dose of docetaxel conducted at the Memorial Sloan-Kettering Cancer Center (New York, NY) demonstrated a 38% response rate with grade 3 or 4 neutropenia in 76% of the patients and a grade 2 or greater rash or infusionrelated reaction in 41% and 3