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Randomised phase II study of standard versus chronomodulated CPT-11 plus chronomodulated 5-fluorouracil and folinic acid in advanced colorectal cancer patients

✍ Scribed by Carlo Garufi; Barbara Vanni; Anna Maria Aschelter; Albina Rita Zappalà; Emilio Bria; Cecila Nisticò; Isabella Sperduti; Francesco Cognetti; Edmondo Terzoli


Book ID
116428549
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
166 KB
Volume
42
Category
Article
ISSN
0959-8049

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Background. Metastatic colorectal cancer is generally incurable. The most active regimen available, 5-fluorouracil(5-FU) and folinic acid (Leucovorin), produces response rates of approximately 25% to 30%. Methyl-lomustine is a nitrosourea with modest activity against colorectal cancer. A randomized