๐”– Bobbio Scriptorium
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Ramipril-associated lichen planus pemphigoides

โœ Scribed by G.S. OGG; B.S. BHOGAL; T. HASHIMOTO; R. COLEMAN; J.N.W.N. BARKER

Book ID
104458502
Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
790 KB
Volume
136
Category
Article
ISSN
0007-0963

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โœฆ Synopsis

We report the first case of lichen planus pemphigoides (LPP) secondary to ingestion of ramipril, an angiotensin-converting enzyme inhibitor. Clinical, histological and immunofluorescent findings were all consistent with a diagnosis of LPP. Linear basement membrane zone (BMZ) staining with IgG and C3 was only seen at the roof of split-skin preparations and circulating autoantibody to the BMZ was present at a titre of 1/100. Controlled immunoblotting of epidermal extracts detected the bullous pemphigoid antigens of 230 and 180 kDa.

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## Abstract A 72-year-old woman had suffered from parapsoriasis en plaque (large plaque type) controlled by topically applied psoralen ultraviolet A (PUVA) therapy. The parapsoriasis lesions gradually disappeared, but numerous tiny red papules with pruritus appeared over the forearms and lower legs