Ramifications of HLA class I polymorphism and population genetics for vaccine development

Reevaluation of the importance of polymo

Reevaluation of the importance of polymorphic HLA class II alleles and amino acids in the susceptibility of individuals of different populations to type I diabetes

✍ Zamani, Mahdi; Cassiman, Jean-Jacques 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 87 KB 👁 2 views

Several publications have shown that certain alleles at the HLA-DRB1, -DQA1, and -DQB1 loci are associated with insulindependent diabetes mellitus (IDDM). Many of these studies have claimed that HLA-DQ␣1 Arg52 and DQ␤1 Asp57 showed the strongest association with IDDM, but these results could not be