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Raman Spectroscopic Study on the Copper(II) Binding Mode of Prion Octapeptide and Its pH Dependence †

✍ Scribed by Miura, Takashi; Hori-i, Ayako; Mototani, Hideyuki; Takeuchi, Hideo

Book ID
126869625
Publisher
American Chemical Society
Year
1999
Tongue
English
Weight
198 KB
Volume
38
Category
Article
ISSN
0006-2960

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✍ Raffaele P. Bonomo; Giuseppe Impellizzeri; Giuseppe Pappalardo; Enrico Rizzarell 📂 Article 📅 2000 🏛 John Wiley and Sons 🌐 English ⚖ 154 KB 👁 1 views

The N-terminal octapeptide repeat region of human prion protein (PrP c ) is known to bind Cu II . To investigate the binding modes of copper in PrP c , an octapeptide Ac-PHGGGWGQ-NH 2 (1), which corresponds to an octarepeat sequence, and a tetrapeptide Ac-HGGG-NH 2 (2) have been synthesised. The cop