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Raman microspectroscopy of the brain tissues in the substantia nigra and MPTP-induced Parkinson's disease

✍ Scribed by C. W. Ong; Z. X. Shen; Y. He; T. Lee; S. H. Tang

Publisher
John Wiley and Sons
Year
1999
Tongue
English
Weight
125 KB
Volume
30
Category
Article
ISSN
0377-0486

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✦ Synopsis

The substantia nigra of the rostral mid-brain of a monkey was studied using Raman microspectroscopy. The white and grey matter could be clearly distinguished and their relative proportions evaluated from the Raman peaks in the 3000 cm-1 region. Raman spectra obtained from the substantia nigra for both treated and untreated samples showed that the process of staining the neuron nuclei a †ected the brain cells and the quality of the Raman spectra from the treated samples was poorer. The brain cells of a monkey su †ering from ParkinsonÏs disease was also studied. Raman spectra collected from the control cells and the diseased cells did not show a clear di †erence.

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