The study of amorphous phase separation
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Adora M. Padilla; Shin G. Chou; Sumit Luthra; Michael J. Pikal
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Article
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2011
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John Wiley and Sons
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English
โ 575 KB
The freezing process is a source of product instability in many freeze-dried pharmaceuticals. During freezing, the solute is concentrated in the interstitial spaces between ice crystals, and phase separation may occur, with likely negative stability implications. Phase separation may involve crystal