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Raloxifene protects cultured human chondrocytes from IL-1β induced damage: A biochemical and morphological study

✍ Scribed by Laura Tinti; Silvia Niccolini; Antonello Lamboglia; Nicola A. Pascarelli; Roberto Cervone; Antonella Fioravanti

Book ID
113589490
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
600 KB
Volume
670
Category
Article
ISSN
0014-2999

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✍ Paola Vicini; Matteo Incerti; Venera Cardile; Floriana Garufi; Simone Ronsisvall 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 115 KB

## Abstract New derivatives of __N__‐benzo[__d__]isothiazol‐3‐yl‐benzamidine **6 a** were synthesized as nonacidic anti‐inflammatory/antidegenerative agents. We investigated the influence of the amidines **6 a**–**j** on the production of NO, PGE~2~, MMP‐3, COX‐2, ROS, and GAGs, key molecules invol