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Radiotracers for a multi-target approach to the diagnosis of Alzheimer's disease

✍ Scribed by Jogeshwar Mukherjee; Elizabeth Head; Rama Pichika; Balasubramaniam Easwaramoorthy; Daphne Collins; Ines Chen; Crystal S. Wang; Neil Saigal; Portia Trinidad; Kathy Kim; Vivien L. Nguyen

Publisher: John Wiley and Sons
Year: 2007
Tongue: French
Weight: 105 KB
Volume: 50
Category: Article
ISSN: 0022-2135
DOI: 10.1002/jlcr.1266

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✦ Synopsis

Abstract

Development of β‐amyloid plaques and neurofibrillary tangles is the hallmark of Alzheimer's disease (AD) and progressively affects the overall functioning of the brain. Noninvasive imaging methods aiding early diagnosis will significantly improve benefits provided by treatments and possibly lead to prevention of AD. We report the development of PET radiotracer methods for β‐amyloid plaques and tangles, nicotinic __α__4__β__2 receptors, serotonin 5HT1A receptors, dopamine D2/D3 receptors and norepinephrine transporters for the study of AD. This multi‐target approach is currently being evaluated in AD transgenic mice models. Copyright © 2007 John Wiley & Sons, Ltd.

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