Radiotracer distribution and excretion study of chlorophenothane in rats

✍ Scribed by R. H. Bishara; G. S. Born; J. E. Christian

• Publisher: John Wiley and Sons
• Year: 1972
• Tongue: English
• Weight: 631 KB
• Volume: 61
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600611206

✦ Synopsis

0 14C-Labeled chlorophenothane was acutely administered orally and intraperitoneally to rats to study the tissue distribution, rate of excretion, and effect of the route of administration.

Five days after dosing, the fat was the tissue with the highest radioactivity irrespective of the route of administration. At the 0.05 significance level, the lungs, spleen. liver, kidneys, and testes of intraperitoneally dosed rats showed greater concentration than those orally dosed. The fecal excretion of thelatter group was higher than those of the former group. The greatest percentage of radioactivity excreted in feces after oral administration occurred in the first 24 hr. Urinary excretion by the two routes was statistically the same.

Negligible T O 2 was detected in the respired air. The rewlts of this experiment support previously reported nonradiotracer studies.