## Background: Diffuse pontine gliomas remain one of the most lethal of pediatric malignancies despite the use of increasingly intensive therapies. we delivered intensive chemotherapy during and following 70.2 gy of hyperfractionated radiation therapy in an attempt to improve survival. ## Procedur
โฆ LIBER โฆ
Radiotherapy with concurrent and adjuvant temozolomide in children with newly diagnosed diffuse intrinsic pontine glioma
โ Scribed by Andrea Chassot; Sandra Canale; Pascale Varlet; Stephanie Puget; Thomas Roujeau; Laura Negretti; Frederic Dhermain; Xavier Rialland; Marie Anne Raquin; Jacques Grill; Christelle Dufour
- Publisher
- Springer US
- Year
- 2011
- Tongue
- English
- Weight
- 452 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0167-594X
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## BACKGROUND. The role of high dose chemotherapy (HDC) in patients with pediatric brain tumors currently is ill-defined. The purpose of this pilot study was to assess the feasibility and the benefit of HDC after radiotherapy in a group of children with newly diagnosed diffuse pontine gliomas. ##