✦ LIBER ✦

Radiosynthesis of high effective specific-activity [123I]SCH 23982 for dopamine D-1 receptor-based SPECT imaging

✍ Scribed by Stephen M. Moerlein; David Parkinson; Michael J. Welch

Publisher: Elsevier Science
Year: 1990
Weight: 478 KB
Volume: 41
Category: Article
ISSN: 0883-2889
DOI: 10.1016/0883-2889(90)90147-9

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✦ Synopsis

The high yield, high-specific activity radiosynthesis of the dopaminergic D-1 receptor-binding ligand [123I]SCH 23982 is described. Using no-carrier-added iododeprotonation of the des-iodo precursor SKF 83692 and column-switching HPLC, [123I]SCH 23982 was isolated in 35-40% radiochemical yield with an effective specific activity of 2250-4000 Ci/mmol and an overall preparation time of 90 min. The procedure outlined here can be employed for the clinical production of [123I]SCH 23982 as a SPECT radiopharmaceutical, as well as [125I]SCH 23982 to be used for in vitro receptor-binding applications.

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