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Radiosensitizing effect of misonidazole in acute and fractionated irradiation of a human osteosarcoma xenograft

✍ Scribed by Einar K. Rofstad; Tor Brustad

Publisher
Elsevier Science
Year
1980
Tongue
English
Weight
604 KB
Volume
6
Category
Article
ISSN
0360-3016

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The goal of this study was to compare, with a human tumor xenograft, two different strategies for increasing tumor response to fractionated irradiation, namely, oxygenating the hypoxic tumor cells with carbogen and nicotinamide, or killing these cells with the hypoxic cytotoxin, tirapazamine (TPZ).