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Radiosensitization in vitro and in vivo by 3-nitrotriazoles

✍ Scribed by Yuta Shibamoto; Koichi Sakano; Ryoji Kimura; Takehiro Nishidai; Sei-Ichi Nishimoto; Koji Ono; Tsutomu Kagiya; Mitsuyuki Abe


Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
455 KB
Volume
12
Category
Article
ISSN
0360-3016

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## Abstract Valproic acid (VA) is a well‐tolerated drug used to treat seizure disorders and has recently been shown to inhibit histone deacetylase (HDAC). Because HDAC modulates chromatin structure and gene expression, parameters considered to influence radioresponse, we investigated the effects of