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Radiosensitization by a dominant negative to DNA polymerase β is DNA polymerase β-independent and XRCC1-dependent

✍ Scribed by Sari Neijenhuis; Adrian C. Begg; Conchita Vens


Book ID
118496509
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
162 KB
Volume
76
Category
Article
ISSN
0167-8140

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## Abstract X‐ray cross complementing 1 (XRCC1) protein has been suggested to bind to DNA single‐strand breaks (SSBs) and organize protein interactions that facilitate efficient DNA repair. Using four site‐specifically modified human XRCC1 mutant expression systems and functional complementation as