Introduction: Although [ 18 F]FDG has been proven as the radioligand of choice for many extracranial tumors, radiolabeled amino acids are preferred for the study of intracerebral tumors with PET because transport mechanisms of large neutral amino acid (LNAA) are upregulated in those tumors. To overc
Radiopharmacology
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- French
- Weight
- 659 KB
- Volume
- 50
- Category
- Article
- ISSN
- 0022-2135
No coin nor oath required. For personal study only.
โฆ Synopsis
Conclusion:
The robust and reproducible remotely-controlled two step/one pot synthesis of [ 18 F]fluoroacetate starting from readily available (methanesulfonyloxy)-acetic acid tert.-butyl ester 3a as a novel labelling precursor represents an alternative to the published procedures. A comparing discussion of data obtained with [ 11 C]acetate in rats and mice will be presented.
๐ SIMILAR VOLUMES
Analogues of the macrocyclic chelator 1,4,8,11-tetraazacyclotetradecane-1,4,8,11-tetraacetic acid (TETA) are currently used as chelators of choice for labeling copper radionuclides to biological molecules. Recently, the "cross-bridged" cyclam complex, 64 Cu(II)-4,11bis(carboxymethyl)-1,4,8,11-tetraa
To demonstrate that radio-immunotherapy i s more effective than the combination of the cold antibody with an equal absorbed dose of gamma radiation we compared gamma irradiation of B-CLL cells in vitro with an alpha-emitter conjugated to an membranous (CD20) and an internalized antibody (CD19). In a
Adenocarcinoma of the pancreas is one of the least understood and most incurable malignancies. Almost all patients with this disease die within 1 year of diagnosis. To facilitate development of novel radiopharmaceuticals for diagnostic and therapeutic uses, in vivo models are need that closely mimic