Radiopharmaceutical for differential diagnosis of tuberculoma: Synthesis of 2−[11C]cyano-isonicotinic acid hydrazide
✍ Scribed by C.W. Somawardhana; Munawwar Sajjad; Richard M. Lambrecht
- Publisher
- Elsevier Science
- Year
- 1991
- Weight
- 444 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0883-2889
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✦ Synopsis
The radiochemical synthesis of 2-['Qyano-isonicotinic acid hydrazide was accomplished. Carbon-l 1 labelled cyano-group was introduced at the 2-position of the pyridine ring of I-methoxy-4-methoxcarbonyl pyridinium methyl sulfate via a Reissert-Kaufmann type reaction. The reaction was Performed on a solid support (silica gel) to yield no-carrier-added methyl 2-["Clcyano-isonicotinate in (32.4 + 12%) (EOB) yield. This method is unique for the incorporation of ["CIHCN to base sensitive substrates. The carbon-l I labelled methyl ester was treated with hydrazine hydrate to obtain 2-["Clcyano-isonicotinic acid hydrazide. The final radiochemical yield was 10% (EOB) and the synthesis time was approximately 35 min.