Radiolytic reduction of nifurtimox: The anaerobic mechanism

✍ Scribed by A. Filali-Mouhim; D. Jore; B. Hickel; C. Ferradini

• Publisher: Elsevier Science
• Year: 1996
• Tongue: English
• Weight: 464 KB
• Volume: 47
• Category: Article
• ISSN: 0969-806X
• DOI: 10.1016/0969-806x(94)00150-i

✦ Synopsis

Abstraet--A radiolysis study of aqueous solutions of Nifurtimox (ArNO 2), an antiparasitic drug, has been performed in the absence of oxygen. The absorption spectra of three ArNO 2 intermediate reduced species have been quantitatively characterized: the radical anion ArNOz, the nitroso derivative ArNO and the 4 e-final reduced product. The study of hydrogen peroxide effect on the ~ radiolysis mechanism has shown that H202 reacts with the ArNO compound.