Radiolabelling optimisation of 7-bromo-5-[123I]-iodo-4-oxo-1,4-dihidroquinoline-2-carboxylic acid: a potential tracer for NMDA SPECT studies

Synthesis of [77Br] 5,7-dibromo-4-oxo-1,

Synthesis of [77Br] 5,7-dibromo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid, a possible SPECT tracer for NMDA receptor studies

✍ F. Dumont; G. Slegers 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 French ⚖ 272 KB

The synthesis of [77Br] 5,7-dibromo-4-oxo-1,4-dihydroquinoline-2-carboxylic acid is described. The labelling is performed in order to obtain a tracer for SPECT studies of the Nmethyl-D-aspartate receptor in human brain. Radiosynthesis was carried out using a nonisotopic nucleophilic halogen exchange

Synthesis and radiolabelling of [123I]-4

Synthesis and radiolabelling of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide, a potential dopamine D3 antagonist for SPECT studies

✍ L. Staelens; F. Dumont; F. De Vos; R. Oltenfreiter; M. Vandecapelle; R.A. Dierck 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 95 KB 👁 1 views

## Abstract Schizophrenia is a devastating mental disorder characterized by relapsing psychotic episodes accompanied with emotional, professional and social decline. The classical dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic neurotransmission is responsible for

Synthesis and radiolabelling of [123I]-4

Synthesis and radiolabelling of [123I]-4-iodo-N-(4-(4-(2-methoxyphenyl)-piperazin-1-yl)butyl)-benzamide, a potential dopamine D3 antagonist for SPECT studies

✍ L. Staelens; F. Dumont; F. De Vos; R. Oltenfreiter; M. Vandecapelle; R. A. Dierc 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 French ⚖ 98 KB 👁 1 views

## Abstract Schizophrenia is a devastating mental disorder characterized by relapsing psychotic episodes accompanied with emotional, professional and social decline. The classical dopamine hypothesis of schizophrenia postulates that hyperactivity of dopaminergic neurotransmission is responsible for

Synthesis of [123I]tert-butyl 8-iodo-5,6

Synthesis of [123I]tert-butyl 8-iodo-5,6-dihydro-5-methyl-6-oxo-4H-imidazo[1,5-a][1,4]benzodiazepine 3-carboxylate, a potential SPECT imaging agent for diazepam-insensitive (DI) benzodiazepine receptors

✍ Xiao-Shu He; Dorota Matecka; Kan Sam Lee; Zi-Qiang Gu; Kenner C. Rice; Garry Won 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 French ⚖ 355 KB 👁 1 views

## Abstract [^123^I]__tert__‐Butyl 8‐iodo‐5,6‐dihydro‐5‐methyl‐6‐oxo‐4__H__‐imidazo [1,5‐a][1,4]benzodiazepine 3‐carboxylate ([^123^I]3), a high affinity and selective radioligand for the diazepam insensitive (DI) benzodiazepine receptor was synthesized in 2 steps from __tert__‐butyl 8‐bromo‐5,6‐di