Radiolabelling of poly(butyl 2-cyanoacrylate) nanoparticles with a technetium-99m-dextran complex

✍ Scribed by Stephen J. Douglas; Stanley S. Davis

• Publisher: John Wiley and Sons
• Year: 1986
• Tongue: French
• Weight: 337 KB
• Volume: 23
• Category: Article
• ISSN: 0022-2135
• DOI: 10.1002/jlcr.2580230506

✦ Synopsis

P o l y ( b u t y 1 2 -c y a n o a c r y l a t e ) n a n o p a r t i c l e s h a v e b e e n r a d i o l a b e l l e d w i t h a 9gmTc-dextran complex t o a l l o w t h e i r p a t t e r n o f b i o d i s t r i b u t i o n t o be f o l l o w e d by u s i n g t h e t e c h n i q u e of gamma s c i n t i g r a p h y . The method i n v o l v e s t h e p r e f o r m i n g of a 9MTc-dextran complex and u s i n g t h i s as a polymeric s t a b i l i s e r d u r i n g t h e f o r m a t i o n o f n a n o p a r t i c l e s . C o p o l y m e r i s a t i o n o f t h i s complex w i t h t h e c y a n o a c r y l a t e monomer r e s u l t s i n t h e r a d i o l a b e l b e i n g c o v a l e n t l y l i n k e d t o t h e n a n o p a r t i c l e m a t r i x w i t h a l a b e l l i n g e f f i c i e n c y o f a p p r o x i m a t e l y 182. The r a d i o l a b e l l e d n a n o p a r t i c l e s s l o w l y d e g r a d e and release t h e a c t i v i t y i n t o b u f f e r s o l u t i o n . The release rate was r e l a t i v e l y u n a f f e c t e d by t h e p r e s e n c e o f plasma p r o t e i n s i n d i c a t i n g t h a t t h e s y s t e m s h o u l d b e s u i t a b l e f o r u s e i n v i v o . Keywords: N a n o p a r t i c l e , c o p o l y m e r i s a t i o n , technetium-99rn-dextran, p o l y ( b u t y 1 2 -c y a n o a c r y l a t e )