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Radiolabeling, preliminary biological evaluation and pet examination in monkey of 5-methyl-6-nitroquipazine — a potential serotonin transporter radioligand

✍ Scribed by J. Sandell; M. Yu; P. Emond; B. Gulyas; Z. Cselenyi; J. Sovago; L. Garreau; H. Hall; S. Chalon; D. Guilloteau; K. Någren; L. Farde; C. Halldin


Book ID
112132867
Publisher
John Wiley and Sons
Year
2001
Tongue
French
Weight
164 KB
Volume
44
Category
Article
ISSN
0022-2135

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## Abstract 4‐Fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)piperazin‐1‐yl]ethyl}benzamide is a full 5‐HT~1A~ agonist with high affinity (__pK__~__i__~=9.3), selectivity and a __c__ log __P__ of 3.045. The corresponding PET radioligand 4‐[^18^F]fluoro‐__N__‐{2‐[4‐(6‐trifluoromethylpyridin‐2‐yl)