Radiolabeling of two 11 C-labeled formylating agents and their application in the preparation of [ 11 C]benzimidazole
β Scribed by Schou, Magnus; Halldin, Christer
- Book ID
- 118762939
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- French
- Weight
- 177 KB
- Volume
- 55
- Category
- Article
- ISSN
- 0022-2135
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## Abstract A method for the production of two new carbonβ11 labelled difunctional radiolabelling precursors, [^11^C]diethyl oxalate, 2, and [^11^C]oxalic acid, 3, is described. Methyl chloroformate was reacted with noβcarrierβadded [^11^C]cyanide to generate the intermediate nitrile, methyl [^11^C
Dimethylphenethylamine (DMPA), a substrate for the B-form of the monoamine oxidase enzyme (MAO, EC 1.4.3.4), was labelled with 11C in two different positions; in the methyl group (M-DMPA) and in the phenethyl group (P-DMPA). M-DMPA was prepared by N-alkylation of methylphenethylamine with [11C]methy