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Radiolabeling of rituximab with 188Re and 99mTc using the tricarbonyl technology

✍ Scribed by Carla Roberta Dias; Simone Jeger; João Alberto Osso Jr; Cristina Müller; Christine De Pasquale; Alexander Hohn; Robert Waibel; Roger Schibli


Book ID
117983554
Publisher
Elsevier Science
Year
2011
Tongue
English
Weight
279 KB
Volume
38
Category
Article
ISSN
0969-8051

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✍ Marie-Laure Biechlin; Amaury du Moulinet d'Hardemare; Marc Fraysse; François-Noë 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 French ⚖ 143 KB

The aim of this study was to improve the radiolabelling of proteins with the 99m Tctricarbonyl-[Tc(I)(CO) 3 ] + core by introducing thiol groups to their structure. To achieve this goal, g-globulins and annexin V were derivatized with mercaptobutyrimidyl groups (MBG) after reaction with 2-iminothiol