Radioiodination of 2′-deoxyuridine: Preparation and preliminary evaluation in tumour-bearing rats

✍ Scribed by P. Goethals; W. Lodewyckx; M. Van Eijkeren; R. Dams

• Publisher: Elsevier Science
• Year: 1994
• Tongue: English
• Weight: 350 KB
• Volume: 45
• Category: Article
• ISSN: 0969-8043
• DOI: 10.1016/0969-8043(94)90003-5

✦ Synopsis

A simple rapid procedure, using a Iodo-bead as oxidizing agent, has been developed for labelling 2'-deoxyuridine on the 5-position of the base with 123I. The labelling yield exceeds 60% and the total production time amounts to only 1 h. Biodistribution studies with 5-[123I]iodo-2'-deoxyuridine on tumour-bearing rats showed an important uptake of activity in tissue with a high cell proliferation rate (tumour, intestine) and in the liver.