𝔖 Bobbio Scriptorium
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Radioiodinated iodobenzylguanidines for diagnosis and therapy

✍ Scribed by A.J. McEwan; P. Wyeth; Duncan Ackery

Publisher
Elsevier Science
Year
1986
Weight
917 KB
Volume
37
Category
Article
ISSN
0883-2889

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✦ Synopsis

Radiolabelled meta-iodobenzylguanidine has been one of the most successful of recent radiopharmaceuticals. In the short period of five years it has been shown to have high diagnostic sensitivity and specificity for many tumours of neuroectodermal origin. Furthermore its excellent concentration in many malignant tumours of this type offers a novel alternative treatment to those available at present.

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The development of fatty acids labelled with iodine-123 is reviewed. The variety of methods for producing 123I and introducing radioiodine into the molecule is discussed and the important points of the biochemical background are recalled with the aim of finding a broad application for 123I-labelled