Radioiodinated estramustine phosphate and estramustine binding protein Antibody accumulate in the prostate of a mouse

✍ Scribed by Stålberg, Kaarlo; Kairemo, Kalevi; Karonen, Sirkka-Liisa; Jekunen, Antti; Taari, Kimmo; Rannikko, Sakari

• Publisher: John Wiley and Sons
• Year: 1997
• Tongue: English
• Weight: 302 KB
• Volume: 32
• Category: Article
• ISSN: 0270-4137
• DOI: 10.1002/(sici)1097-0045(19970615)32:1<1::aid-pros1>3.0.co;2-q

✦ Synopsis

Background:

The purpose of this study was to determine the distribution of radioiodinated estramustine (ri-emp) and a radioiodinated antibody against estramustine binding protein (ri-embp-ab) in mice.

Methods:

Ri-emp and ri-embp-ab were injected in male mice intravenously, and the activities of tissue samples were measured 1-31 hr from the injection. pure iodine-125 (ri) was used as a control.

Results:

Ri-emp accumulated in the prostate, which contained 2.6% of injected activity (id) per gram tissue at 7 hr. the liver had an activity of 21.4% id/g at 1 hr, which decreased as ri-emp was secreted in bile. the lung contained 2.3% id/g at 7 hr, and it retained the activity longer than the prostate. ri-embp-ab accumulated in the prostate: the activity was 2.9% id/g at 7 hr. the gallbladder contained 6.5% id/g at 7 hr.

Conclusions:

Due to its cytotoxic and radiosensitizing properties, ri-emp can possibly be used for treating prostate cancer and other tumors.