✦ LIBER ✦

Radioimmunoguided surgery in gastric cancer using 131-I labeled monoclonal antibody 3H11

✍ Scribed by Dr. Guangwei Xu; Meiying Zhang; Baoguo Liu; Zhenfu Li; Baohe Lin; Xiaobao Xu; Maolin Jin; Jiyou Li; Jian Wu; Zhiwei Dong

Book ID: 104594208
Publisher: John Wiley and Sons
Year: 1994
Tongue: English
Weight: 478 KB
Volume: 10
Category: Article
ISSN: 8756-0437
DOI: 10.1002/ssu.2980100205

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A clinical trial of radioimmunoguided surgery (RIGS) using 131‐I labeled monoclonal antibody (MAb) 3H11 was performed on 25 cases with gastric cancer in this study. The results showed that the route of the administration of radiolabeled MAb is the key point of successful RIGS for gastric cancer. The RIGS in 19 cases in the group of submucosal injection via endoscope was very satisfying. For the detection of metastatic lymph nodes, the sensitivity rate of RIGS was 99.2% (118/119), the specificity, 97.7% (43/44), and the accuracy 98.8% (161/163). The accuracy rate in detecting tumor infiltration of the gastric wall was 95.9% (94/98), the sensitivity 94.6% (35/37), and the specificity 96.7% (59/61). Thus, the use of RIGS may improve the radical resectability rate and possibly the overall survival rate in patients with gastric cancer. © 1994 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

Role of radioimmunoguided surgery using

Role of radioimmunoguided surgery using Iodine-125-labeled B72.3 monoclonal antibody in gastric cancer surgery

✍ Enzo Lucisano; Sergio Bertoglio 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 26 KB

Uniform and accurate staging of gastric cancer is essential to predict prognosis and assess the effectiveness of treatment strategies. An appropriate amount of surgical resection of the primary tumor and lymph node dissection appears to be fundamental for such staging. In seven out of 10 patients wh

Direct labelling of anti-gastric cancer

Direct labelling of anti-gastric cancer monoclonal antibody 3H11 with99mTc

✍ Yang Zhi; Zhang Meiying; Lin Baohe; Han Yan; Mu Aping; Zhang Qing; Xu Xiaobao 📂 Article 📅 1996 🏛 Springer 🌐 English ⚖ 879 KB

Radioimmunotherapy of small-cell lung ca

Radioimmunotherapy of small-cell lung cancer xenografts using 131I-labelled anti-NCAM monoclonal antibody 123C3

📂 Article 📅 1996 🏛 Elsevier Science 🌐 English ⚖ 135 KB

Phase I Radioimmunotherapy Trial with Io

Phase I Radioimmunotherapy Trial with Iodine-131—Labeled Humanized MN-14 Anti—Carcinoembryonic Antigen Monoclonal Antibody in Patients with Metastatic Gastrointestinal and Colorectal Cancer

✍ George Hajjar; Robert M. Sharkey; Jack Burton; Chu-Hui Zhang; Dion Yeldell; Alex 📂 Article 📅 2002 🏛 CIG Media Group, LP. 🌐 English ⚖ 195 KB

Phase-I/II radio-immunotherapy study wit

Phase-I/II radio-immunotherapy study with iodine-131-labeled anti-CEA monoclonal antibody F6 F(ab′)2 in patients with non-resectable liver metastases from colorectal cancer

✍ Marc Ychou; André Pelegrin; Patrick Faurous; Bruno Robert; Jean-Claude Saccavini 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 French ⚖ 85 KB 👁 2 views

Experimental studies in nude mice with human coloncarcinoma grafts demonstrated the therapeutic efficiency of F(abЈ) 2 fragments to carcinoembryonic antigen (CEA) labeled with a high dose of 131 Iodine. A phase I/II study was designed to determine the maximum tolerated dose of 131 I-labeled F(abЈ) 2