𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Radioimmunoassay typing gives a more precise definition of the HLA association of Type I (insulin-dependent) diabetes

✍ Scribed by R. Tosi; M. Vela; D. Adorno; A. Longo; F. Papola; D. Maccarone; D. Centis; N. Tanigaki; M. P. Raponi; A. Candela; L. Campea; M. Orsini; G. B. Ferrara

Book ID
104789194
Publisher
Springer
Year
1986
Tongue
English
Weight
503 KB
Volume
29
Category
Article
ISSN
0012-186X

No coin nor oath required. For personal study only.

✦ Synopsis

The problem of the HLA association of Type t (insulin-dependent) diabetes was re-examined by testing Class II antigenic specificities detectable by radioimmunoassay. Established (DRw53, DQwl, DQw2, DQw3) as well as newly described (DC5, DCalpha3) specificities were typed. The data obtained suggest that the association with DR3 and DR4 is secondary to that with DQ specificities in linkage disequilibrium with DR3 and DR4.

πŸ“œ SIMILAR VOLUMES

The genetic susceptibility to type 1 (in
The genetic susceptibility to type 1 (insulin-dependent) diabetes: Analysis of the HLA-DR association
✍ E. Wolf; K. M. Spencer; A. G. Cudworth πŸ“‚ Article πŸ“… 1983 πŸ› Springer 🌐 English βš– 725 KB

HLA-DR and MT1, MT2, MT3 genotypes have been investigated in 123 Type 1 (insulin-dependent) diabetic subjects and their families. Ninety-eight percent of probands possessed either DR3 (relative risk = 5.0), or DR4 (relative risk = 6.8) or both antigens (relative risk = 14.3), emphasizing the strong