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Radioimmunoassay of carcinoembryonic antigen in extracts of human colon and stomach

✍ Scribed by F. Martin; M. S. Martin

Publisher
John Wiley and Sons
Year
1972
Tongue
French
Weight
431 KB
Volume
9
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

Radioimmunoassay is used to characterize and quantitatively determine CEA in perchloric extracts of human stomach and intestine, normal, foetal or cancerous. High concentrations of CEA were found in primary adenocarcinomas of the colon and in their metastases to liver. CEA could also be detected, in lesser amounts, in six colonic mucosa removed for non‐cancerous diseases, in two specimens of foetal gut and in five out of six gastric carcinomas. On the other hand, CEA could not be found in non‐cancerous gastric mucosa. Comparison of inhibition curves shows that CEA present in non‐cancerous colon and purified CEA isolated from metastatic colonic cancer have the same immunological reactivity.

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