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Radioimmunoassay for danazol in human and monkey plasma

✍ Scribed by J. E. Peterson; M. E. King; W. F. Banks; J. F. Baker; A. F. Jensen; R. W. Ross Jr.; S. Clemans; J. Edelson

Publisher: John Wiley and Sons
Year: 1978
Tongue: English
Weight: 476 KB
Volume: 67
Category: Article
ISSN: 0022-3549
DOI: 10.1002/jps.2600671026

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✦ Synopsis

A sensitive method is described for the radioimmunoassay of danazol in monkey and human plasma. Antiserum was developed in rabbits, and a second antibody was used to separate bound from free danazol. The radioimmunoassay was specific for danazol, and the limit of detection ranged from 1.4 to 2.8 ng/ml. Exogeneous danazol could be quantitated accurately in both monkey and human plasma. The radioimmunoassay results agreed with values obtained by inverse isotope dilution after intravenous administration of 14C-danazol to monkeys. The assay was used successfully to measure danazol in plasma from human volunteers receiving 200 mg of danazol.

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