Radiographic changes in the femoral endosteal surface associate with increased bone turnover, decreased cortical width, and low bone density

The type 2 deiodinase Thr92Ala polymorph

The type 2 deiodinase Thr92Ala polymorphism is associated with increased bone turnover and decreased femoral neck bone mineral density

✍ Karen A Heemstra; Hendrieke Hoftijzer; Wendy M van der Deure; Robin P Peeters; N 📂 Article 📅 2010 🏛 American Society for Bone and Mineral Research 🌐 English ⚖ 124 KB

## Abstract The role of type 2 deiodinase (D2) in the human skeleton remains unclear. The D2 polymorphism Thr92Ala has been associated with lower enzymatic activity, which could result in lower local triiodothyronine (T~3~) availability in bone. We therefore hypothesized that the D2 Thr92Ala polymo