Radiofrequency radiation-induced calcium ion efflux enhancement from human and other neuroblastoma cells in culture

✍ Scribed by Dr. S. K. Dutta; B. Ghosh; C. F. Blackman

• Publisher: John Wiley and Sons
• Year: 1989
• Tongue: English
• Weight: 389 KB
• Volume: 10
• Category: Article
• ISSN: 0197-8462
• DOI: 10.1002/bem.2250100208

✦ Synopsis

To test the generality of radiofrequency radiation-induced changes in 4sCa2+ efflux from avian and feline brain tissues, human neuroblastoma cells were exposed to electromagnetic radiation at 147 MHz, amplitude-modulated (AM) at 16 Hz, at specific absorption rates (SAR) of 0.1, 0.05, 0.01, 0.005, 0.001, and 0.0005 W/kg. Significant 4sCa2+ efflux was obtained at SAR values of 0.05 and 0.005 Wikg. Enhanced efflux at 0.05 W/kg peaked at the 13-16 Hz and at the 57.5-60 Hz modulation ranges. A Chinese hamster-mouse hybrid neuroblastoina was also shown to exhibit enhanced radiation-induced "Ca2+ efflux at an SAR of 0.05 Wikg, using 147 MHz, AM at 16 Hz. These results confirm that amplitude-modulated radiofrequency radiation can induce responses in cells of nervous tissue origin from widely different animal species, including humans. The results are also consistent with the repoits of similar findings in avian and feline brain tissues and indicate the general nature of the phenomenon.