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Radiochemical synthesis and biodistribution of a novel maxi-K potassium channel opener

✍ Scribed by Dale O Kiesewetter; Elaine M Jagoda; John E Starrett Jr; Valentin K Gribkoff; Piyasena Hewawasam; Nugahally Srinivas; Daniel Salazar; William C Eckelman


Book ID
117687786
Publisher
Elsevier Science
Year
2002
Tongue
English
Weight
153 KB
Volume
29
Category
Article
ISSN
0969-8051

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## Abstract Currently, NN414, a potent __Ξ²__‐cell selective potassium channel opener, is undergoing clinical trials for the treatment of type 2 diabetes. Here, we report the synthesis of carbon‐14 and stable isotope labelled NN414 for use in metabolic studies and as an internal standard in pharmaco