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Radiobrominated spiroperidol for the study of dopamine D2 receptors

✍ Scribed by Onofre T. De Jesus; Arnold M. Friedman

Book ID
103919792
Publisher
Elsevier Science
Year
1986
Weight
597 KB
Volume
37
Category
Article
ISSN
0883-2889

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✦ Synopsis

Some neuropsychiatric disorders have been suggested to be related to the CNS dopaminergic system. In order to probe this neurotransmitter system, radiobrominated spiroperidol, a potent dopamine (DA) D2-receptor antagonist, was developed. This review deals with the routine synthesis of [75, 76, or 77Br]-p-bromospiroperidol (BrSP), its validation as a radiopharmaceutical directed to DA D2 receptors, and the imaging studies which have been done using this radioligand with either single photon tomography (SPECT) or positron tomography (PET). [*Br]BrSP will be compared to other D2 ligands currently available. The present state and future direction of DA receptor research, in particular, the quantitative aspects, will be discussed.

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