Radioactive particle tracking in a lab-scale conical fluidized bed dryer containing pharmaceutical granule
✍ Scribed by Pankaj Khanna; Todd Pugsley; Helen Tanfara; Hubert Dumont
- Publisher
- John Wiley and Sons
- Year
- 2008
- Tongue
- English
- Weight
- 283 KB
- Volume
- 86
- Category
- Article
- ISSN
- 0008-4034
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✦ Synopsis
Abstract
Radioactive particle tracking (RPT) has been used to study the motion of the particulate phase in a bench‐scale conical fluidized bed containing dried pharmaceutical granule. RPT revealed that there is a distinct circulation pattern of the granule with particles moving upwards at high velocities near the centre of the bed and falling slowly near the walls. There was also a localized region near the centre of the bed where particles moved downward rapidly. The particle size distribution (PSD) of the granule had an appreciable impact on particle motion with a wide PSD leading to larger fluctuations in particle velocity as well as poorer granule mixing.