Radioactive gold nanoparticles in cancer therapy: therapeutic efficacy studies of GA-198AuNP nanoconstruct in prostate tumor–bearing mice
✍ Scribed by Nripen Chanda; Para Kan; Lisa D. Watkinson; Ravi Shukla; Ajit Zambre; Terry L. Carmack; Hendrik Engelbrecht; John R. Lever; Kavita Katti; Genevieve M. Fent; Stan W. Casteel; C. Jeffrey Smith; William H. Miller; Silvia Jurisson; Evan Boote; J. David Robertson; Cathy Cutler; Marina Dobrovolskaia; Raghuraman Kannan; Kattesh V. Katti
- Publisher
- Elsevier Science
- Year
- 2010
- Tongue
- English
- Weight
- 850 KB
- Volume
- 6
- Category
- Article
- ISSN
- 1549-9634
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✦ Synopsis
From the clinical editor:
In this study, the biocompatibility and cancer therapeutic applications of glycoprotein (ga) functionalized gold nanoparticles containing b-emitting au-198 are described in scid mice bearing human prostate tumor xenografts. the findings of significant therapeutic efficacy, good in vivo tolerance and non-toxic features make these particles ideal candidates for future human applications.