Radicals in enzymatic reactions

✍ Scribed by Perry A Frey

• Book ID: 104414951
• Publisher: Elsevier Science
• Year: 1997
• Tongue: English
• Weight: 979 KB
• Volume: 1
• Category: Article
• ISSN: 1367-5931
• DOI: 10.1016/s1367-5931(97)80072-5

✦ Synopsis

Spectroscopic and kinetic evidence for substrate-based radicals in the reactions of lysine 2,3-aminomutase and methane monooxygenase has recently been gathered. Evidence for a protein-based thiyl radical in the mechanism of the action of ribonucleotide reductase has been correlated with the proposed mechanism involving substrate-based radicals. Controversies have arisen about the mechanisms of ribonucleotide reductase and methane monooxygenase reactions.