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Radical Cyclization in Heterocycle Synthesis. Part 13. Sulfanyl Radical Addition—Cyclization of Oxime Ethers and Hydrazones Connected with Alkenes for Synthesis of Cyclic β-Amino Acids.

✍ Scribed by Okiko Miyata; Kanami Muroya; Tomoko Kobayashi; Rina Yamanaka; Seiko Kajisa; Junko Koide; Takeaki Naito


Publisher
John Wiley and Sons
Year
2010
Weight
35 KB
Volume
33
Category
Article
ISSN
0931-7597

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✍ O. MIYATA; K. MUROYA; J. KOIDE; T. NAITO 📂 Article 📅 2010 🏛 John Wiley and Sons ⚖ 32 KB 👁 1 views

A Concise Synthesis of Rigidified β-Amino Acids via Sulfanyl Radical Addition-Cyclization of Oxime Ethers and Hydrazones. -Sulfanyl radical cyclization of alkenyl-tethered oxime ethers and hydrazones (I) provides cis/trans mixtures of the cyclized products (III) and (IV). The cyclopentylamines (III