Radical aromatic substitution via atom-transfer addition

✍ Scribed by Jeffrey H. Byers; John E. Campbell; Faith H. Knapp; Jameson G. Thissell

• Book ID: 104261098
• Publisher: Elsevier Science
• Year: 1999
• Tongue: French
• Weight: 259 KB
• Volume: 40
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(99)00304-4

✦ Synopsis

New methodology for radical aromatic substitution has been developed involving the addition of electron-deficient radicals to unprotected pyrroles and indole. This non-oxidative process is presumed to be occurring via atom-transfer addition of suitable organoiodides and bromides with subsequent non-radical elimination of HI or HBr, respectively. The process also occurs under stannane-free conditions.