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Radiation-induced bystander effect: Activation of signaling molecules in K562 erythroleukemia cells

✍ Scribed by Anirban Kumar Mitra; Malini Krishna

Publisher
John Wiley and Sons
Year
2007
Tongue
English
Weight
274 KB
Volume
100
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Gap junction independent signaling mechanism was investigated using K562 human erythroleukemia cells. They were exposed to 2, 5, or 10 Gy of ^60^Co γ irradiation, the medium isolated 20 min post‐irradiation and added to fresh cells. Evidence of radiation‐induced bystander effect was observed wherein there was activation of p21, nuclear factor‐κB (NF‐κB), Bax, Bcl‐2 and cleavage of poly(ADP‐ribose) polymerase in bystander cells. The study implicates the involvement of signaling molecules released into the medium and factors like stable free radicals that are generated in the surrounding medium. The response elicited appears to be primarily via NF‐κB and p21 activation. J. Cell. Biochem. 100: 991–997, 2007. © 2006 Wiley‐Liss, Inc.

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