Radiation-induced apoptosis in normal and pre-neoplastic mammary glands in vivo: Significance of gland differentiation and p53 status

Radiation-induced tumorigenesis in prene

Radiation-induced tumorigenesis in preneoplastic mouse mammary glands in vivo: Significance of p53 status and apoptosis

✍ Daniel Medina; L. Clifton Stephens; Pedro J. Bonilla; C. Annette Hollmann; Denis 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 573 KB

In mouse mammary tumorigenesis, p53 mutations facilitate tumorigenesis in concert with other oncogenic alterations. Ionizing radiation enhances tumorigenesis in preneoplastic mammary outgrowth lines and induces p53-dependent apoptosis. We asked if normal p53 function modulates radiation-induced tumo