Radiation-Induced Alteration of Pain-Related Signals in an Animal Model with Bone Invasion from Cancer

Local irradiation in combination with be

Local irradiation in combination with bevacizumab enhances radiation control of bone destruction and cancer-induced pain in a model of bone metastases

✍ Pawel Zwolak; Arkadiusz Z. Dudek; Vidya D. Bodempudi; Julia Nguyen; Robert P. He 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 314 KB

## Abstract Skeletal metastases are a major source of morbidity for cancer patients. The purpose of this study was to evaluate the effects of megavoltage irradiation and antiangiogenic therapy on metastatic bone cancer. A tumor xenograft model was prepared in C3H/Scid mice using 4T1 murine breast c