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Radiation dose to the thyroid in the treatment of acute lymphoblastic leukemia (ALL)

✍ Scribed by Rogers, Paul C. J. ;Fryer, Christopher J. H. ;Hussein, Sherali

Publisher
John Wiley and Sons
Year
1982
Tongue
English
Weight
193 KB
Volume
10
Category
Article
ISSN
0098-1532

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✦ Synopsis

Abstract

Sixteen children who received cranial irradiation for CNS prophylaxis of leukemia were evaluated for dose of radiation received to the thyroid. Radiation dose received by the thyroid varied between 2.8 to 7.5% of the given dose to the cranium. This is sufficient radiation to increase the risk of long‐term thyroid pathology.

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## Abstract The standard dose of clofarabine is 52 mg/m^2^ for pediatrics and 40 mg/m^2^ in adults. Clofarabine dosed at 52 mg/m^2^ was used in adult patients with refractory ALL to maximize response before allo‐HSCT. All patients had a significant response to therapy. Published pharmacokinetic ana