Radial glial cell development and transformation are disturbed inreeler forebrain
✍ Scribed by Hunter-Schaedle, Kim E.
- Book ID
- 101258300
- Publisher
- John Wiley and Sons
- Year
- 1997
- Tongue
- English
- Weight
- 457 KB
- Volume
- 33
- Category
- Article
- ISSN
- 0022-3034
No coin nor oath required. For personal study only.
✦ Synopsis
Radial glia are among the earliest logic mutant mouse reeler provides a genetic model cell types to differentiate in the developing mammalian forebrain. Glial fibers span the early cortical wall, for analysis of RF60 function. Radial glia in reeler forming a dense scaffold; this persists throughout corcortex are shown to be poorly differentiated and the ticogenesis, providing a cellular substrate which supradial scaffold is shown to be maintained for a shorter ports and directs the migration of young neurons. Altime than normal. Furthermore, although astroglial though the mechanisms regulating radial glial cell decells from normal cortex are induced to elaborate a velopment are poorly understood, a secreted cortical radial phenotype by RF60, reeler astroglia show an radial glial differentiation signal was recently identiimpaired differentiation response to this. These findfied in the embryonic mouse forebrain. This signal is ings suggest that an intrinsic defect in glial differentiaabundant at the time radial glia function to support tion contributes to the phenotype of abnormal cortical neuronal migration, and down-regulated perinatally, lamination seen in reeler mouse, and indicate that when radial glia are known to undergo transformation RF60 may play a critical role in normal cortical into astrocytes. Therefore, it seems that this signal patterning.