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Rad GTPase induces cardiomyocyte apoptosis through the activation of p38 mitogen-activated protein kinase

✍ Scribed by Zhongcui Sun; Ji Zhang; Jifeng Zhang; Chunlei Chen; Quan Du; Lin Chang; Chunmei Cao; Ming Zheng; Minerva T. Garcia-Barrio; Yuqing E. Chen; Rui-Ping Xiao; Jieming Mao; Xiaojun Zhu

Book ID: 116301735
Publisher: Elsevier Science
Year: 2011
Tongue: English
Weight: 515 KB
Volume: 409
Category: Article
ISSN: 0006-291X
DOI: 10.1016/j.bbrc.2011.04.104

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## Abstract Signaling events, including Rho GTPases and protein kinase C (PKC), are involved in cardiac hypertrophy. However, the mechanisms by which these pathways cooperate during the hypertrophic process remain unclear. Using an in vitro cyclic stretch model with neonatal rat cardiomyocytes, we