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(R)- or (S)-4-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl)benzoic acid as a new chiral auxiliary for solid phase asymmetric Diels–Alder reactions

✍ Scribed by Rhalid Akkari; Monique Calmès; Françoise Escale; Julien Iapichella; Marc Rolland; Jean Martinez


Book ID
108283793
Publisher
Elsevier Science
Year
2004
Tongue
English
Weight
392 KB
Volume
15
Category
Article
ISSN
0957-4166

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(S)-(3-Hydroxy-4,4-dimethyl-2-oxopyrroli
✍ Rhalid Akkari; Monique Calmès; Delphine Di Malta; Françoise Escale; Jean Martine 📂 Article 📅 2003 🏛 Elsevier Science 🌐 English ⚖ 166 KB

Diastereoselective additions of the resin-supported (S)-(3-hydroxy-4,4-dimethyl-2-oxopyrrolidin-1-yl) acetic acid to phthalimidomethyl aryl ketenes allow solid phase preparation of b 2 -homoarylglycines with reasonable degrees of stereoselectivity.