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R 1626: encouraging antiviral activity in patients with hepatitis C

Book ID
120842348
Publisher
Adis International Limited (now part of Wolters Kluwer Health)
Year
2008
Weight
133 KB
Volume
&NA;
Category
Article
ISSN
1173-8324

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โœ Stuart K. Roberts; Graham Cooksley; Gregory J. Dore; Richard Robson; David Shaw; ๐Ÿ“‚ Article ๐Ÿ“… 2008 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 511 KB

The nucleoside analog R1479 is a potent and highly selective inhibitor of nonstructural protein 5B-directed hepatitis C virus (HCV) replication in vitro. R1626, a tri-isobutyl ester prodrug of R1479, was developed to increase bioavailability and improve antiviral activity. A multicenter, observer-bl