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Quinone toxicity in hepatocytes without oxidative stress

✍ Scribed by Luisa Rossi; Gregory A. Moore; Sten Orrenius; Peter J. O'Brien

Book ID
115706856
Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
1006 KB
Volume
251
Category
Article
ISSN
0003-9861

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The toxic effects of compounds which undergo redox cycling via enzymatic one-electron reduction are reviewed. First of all, the enzymatic reduction of these compounds leads to reactive intermediates, mainly radicals which react with oxygen, whereby superoxide anion radicals are formed. Further oxyge